Alobar Holoprosencephaly

What is Holoprosencephaly?

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The forebrain normally develops around fifth or sixth week of pregnancy. In cases of Holoprosencephaly, the forebrain fails to divide into bilateral hemispheres. This results in defects of the brain, as well as facial malformations. Holoprosencephaly falls into three classes: 1. Alobar Holoproencephaly is when the brain does not divided at all. This is usually associated with severe facial deformities. 2. Semilobar Holoprosencephaly is when the brain’s hemispheres have somewhat divided, causes an intermediate form of the disorder. 3. Lobar Holoprosencephaly is when there is more separation between brain hemispheres. This is the least severe form, and the fetal brain may be nearly normal. According […]