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What is Wolf-Hirschshorn Syndrome?

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Wolf-Hirschhorn syndrome (WHS) is a condition that results when there is a deletion on the short arm of chromosome 4. This missing genetic material results in severe developmental delays and seizures. It is associated with variety of birth defects including microcephaly (small head size), cranial asymmetry, heart defects, curvature of the spine and cleft lip and/or palate. Prognosis depends on what birth defects are present. It is estimated that around 35% of WHS patients die within the first two years of life. Children with WHS often exhibit severe to profound cognitive and physical disabilities.   For more information about Wolf-Hirschshorn Syndrome, visit: Wolf-Hirschorn.org – Wolf-Hirschshorn Syndrome OMIM – Wolf-Hirschchorn Syndrome Medscape – Wolf-Hirschshorn Syndrome […]

Stories

What is Cytomegalovirus (CMV)?

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Cytomegalovirus (CMV) poses a risk to fetal development only when contracted during the first half of pregnancy. Only 40% of these fetuses will develop the infection and of those, only 5 to 15% will have symptoms at birth. In a severely affected fetus, CMV may result in intrauterine growth restriction (IUGR), microcephaly, calcification in the brain, cognitive disabilities, hearing loss, low blood platelet count and liver enlargement. Recurrent maternal CMV infection (a CMV infection contracted before the pregnancy) does not pose serious risks to the fetus.   Centers for Disease Control – CMV Congential Infection Perinatology – Diagnosis & Management of CMV Infection in Pregnancy Mother-to-Baby – Cytomegalovirus (CMV) […]