Osteogenesis Imperfecta (OI) results from a lack of collagen and causes very weak bones which are easily fractured. In severe cases (type II) even a fetus in the amniotic sac will have bone fractures as early a 16 weeks gestation. Infants with OI type II are often not viable beyond the first year of life. Severity of OI varies by individual, but symptoms can includes numerous broken bones, loose joints, dental problems, severe curvature of the spine and hearing loss.

For more information on Osteogenesis Imperfecta, visit:

Medline Plus – Ostegenesis Imperfecta

Genetic Home Reference – Osteogenesis Imperfecta

OMIM – Osteogenesis Imperfecta

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